Bioactivity Comments

IL-34-induced increase in monocyte viability is inhibited by the CSF1R inhibitor GW-2580 [3]. IL-34 sustains inflammatory pathways in the gut [2] and has been associated with obesity, chronic inflammation, and insulin resistance [1].

Natural/Endogenous Targets
Target colony stimulating factor 1 receptor

Selectivity at catalytic receptors
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Target Sp. Type Action Value Parameter Concentration range (M) Reference colony stimulating factor 1 receptor Hs Agonist Agonist - - - 3 ⤷ [3]