pimozide

Ligand id: 90

Name: pimozide

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 7
Topological polar surface area 35.58
Molecular weight 461.23
XLogP 7.8
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
5-HT7 receptor Rn Antagonist Antagonist 9.3 pKi - 7
pKi 9.3 [7]
D2 receptor Hs Antagonist Antagonist 7.0 – 8.8 pKi - 1,9
pKi 7.0 – 8.8 [1,9]
D3 receptor Hs Antagonist Antagonist 7.0 – 8.6 pKi - 1,9
pKi 7.0 – 8.6 [1,9]
D2 receptor Rn Antagonist Antagonist 7.6 pKi - 10
pKi 7.6 [10]
D3 receptor Rn Antagonist Antagonist 7.4 pKi - 10
pKi 7.4 [10]
5-HT2A receptor Hs Antagonist Antagonist 7.1 – 7.7 pKi - 3-4
pKi 7.1 – 7.7 [3-4]
5-HT6 receptor Rn Antagonist Antagonist 7.2 pKi - 7
pKi 7.2 [7]
5-HT1A receptor Hs Antagonist Antagonist 6.8 pKi - 6
pKi 6.8 [6]
H1 receptor Hs Antagonist Antagonist 6.2 pKi - 4
pKi 6.2 [4]
Selectivity at ion channels
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
Kir3.2 Mm Gating inhibitor Antagonist 5.5 pEC50 - 2
pEC50 5.5 Data obtained using Kir3.1/3.2 heteromer [2]
Voltage: -70.0 mV
Cav3.1 Rn Channel blocker Antagonist 7.5 pIC50 - 8
pIC50 7.5 [8]
Voltage: -100.0 mV
Cav3.3 Hs Channel blocker Antagonist 7.5 pIC50 - 8
pIC50 7.5 [8]
Voltage: -100.0 mV
Cav3.2 Rn Channel blocker Antagonist 7.3 pIC50 - 8
pIC50 7.3 [8]
Voltage: -100.0 mV
Kv1.8 Hs Channel blocker - 6.5 pIC50 - 5
pIC50 6.5 [5]