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Synonyms: RG-7221 | RG7221 | RO5520985
Compound class:
Antibody
Comment: Vanucizumab is an investigational bi-specific monoclonal antibody, with potential anti-neoplastic activity being developed by Hoffmann-La Roche [1-2]. Vanucizumab simultaneously targets angiopoietin 2 (ANGPT2) and vascular endothelial growth factor A (VEGFA).
Annotated peptide sequences for this antibody are available from its IMGT/mAb-DB record. BLAST seuqence analysis reveals 100% matches with peptide sequences claimed in patent US8945552 and likely identify XMab1 and XMab2 as candidates for vanucizumab [1]. |
| Bioactivity Comments |
| XMab1 in [1] was used to produce binding affinity data. |
| Selectivity at ligand targets | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
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