altiratinib

Ligand id: 9174

Name: altiratinib

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 3
Rotatable bonds 11
Topological polar surface area 109.42
Molecular weight 510.15
XLogP 5.13
No. Lipinski's rules broken 2

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at human catalytic receptors
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
TEK receptor tyrosine kinase Inhibitor Inhibition 8.6 pIC50 - 1
pIC50 8.6 (IC50 2.4x10-9 M) [1]
MET proto-oncogene, receptor tyrosine kinase Inhibitor Inhibition 8.6 pIC50 - 1
pIC50 8.6 (IC50 2.7x10-9 M) [1]
kinase insert domain receptor Inhibitor Inhibition 8.0 pIC50 - 1
pIC50 8.0 (IC50 9.2x10-9 M) [1]