eCF506

Ligand id: 9186

Name: eCF506

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 10
Hydrogen bond donors 2
Rotatable bonds 10
Topological polar surface area 123.66
Molecular weight 510.31
XLogP 2.13
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
eCF506 is >950-fold selective for SRC kinases over ABL kinase [1]. IC50s for inhibition of the receptor tyrosine kinases KIT, mTOR, PDGFRα and RET are all >1000 nM [1].
Selectivity at human enzymes
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
FGR proto-oncogene, Src family tyrosine kinase Inhibitor Inhibition >9.3 pIC50 - 1
pIC50 >9.3 (IC50 <5x10-10 M) [1]
LCK proto-oncogene, Src family tyrosine kinase Inhibitor Inhibition >9.3 pIC50 - 1
pIC50 >9.3 (IC50 <5x10-10 M) [1]
SRC proto-oncogene, non-receptor tyrosine kinase Inhibitor Inhibition >9.3 pIC50 - 1
pIC50 >9.3 (IC50 <5x10-10 M) [1]
YES proto-oncogene 1, Src family tyrosine kinase Inhibitor Inhibition >9.3 pIC50 - 1
pIC50 >9.3 (IC50 <5x10-10 M) [1]
LYN proto-oncogene, Src family tyrosine kinase Inhibitor Inhibition 9.1 pIC50 - 1
pIC50 9.1 (IC50 8x10-10 M) [1]
FYN proto-oncogene, Src family tyrosine kinase Inhibitor Inhibition 8.7 pIC50 - 1
pIC50 8.7 (IC50 2.1x10-9 M) [1]
fyn related Src family tyrosine kinase Inhibitor Inhibition 8.6 pIC50 - 1
pIC50 8.6 (IC50 2.8x10-9 M) [1]
HCK proto-oncogene, Src family tyrosine kinase Inhibitor Inhibition 8.6 pIC50 - 1
pIC50 8.6 (IC50 2.8x10-9 M) [1]
BLK proto-oncogene, Src family tyrosine kinase Inhibitor Inhibition 8.3 pIC50 - 1
pIC50 8.3 (IC50 5.4x10-9 M) [1]
ABL proto-oncogene 1, non-receptor tyrosine kinase Inhibitor Inhibition 6.3 pIC50 - 1
pIC50 6.3 (IC50 4.79x10-7 M) [1]