eCF506   Click here for help

GtoPdb Ligand ID: 9186

Synonyms: derivative 11a [PMID: 27115835]
PDB Ligand
Compound class: Synthetic organic
Comment: eCF506 is a potent and selective inhibitor of SRC family kinases, with activity against breast cancer cells in vitro and in vivo. Design and discovery of this compound is reported in [1].
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 9
Hydrogen bond donors 2
Rotatable bonds 10
Topological polar surface area 123.66
Molecular weight 510.31
XLogP 3.05
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES COc1cc(ccc1NC(=O)OC(C)(C)C)c1nn(c2c1c(N)ncn2)CCN1CCC(CC1)N(C)C
Isomeric SMILES COc1cc(ccc1NC(=O)OC(C)(C)C)c1nn(c2c1c(N)ncn2)CCN1CCC(CC1)N(C)C
InChI InChI=1S/C26H38N8O3/c1-26(2,3)37-25(35)30-19-8-7-17(15-20(19)36-6)22-21-23(27)28-16-29-24(21)34(31-22)14-13-33-11-9-18(10-12-33)32(4)5/h7-8,15-16,18H,9-14H2,1-6H3,(H,30,35)(H2,27,28,29)
InChI Key GMPQGWXPDRNCBL-UHFFFAOYSA-N
Bioactivity Comments
eCF506 is >950-fold selective for SRC kinases over ABL kinase [1]. IC50s for inhibition of the receptor tyrosine kinases KIT, mTOR, PDGFRα and RET are all >1000 nM [1].
Selectivity at enzymes
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
FGR proto-oncogene, Src family tyrosine kinase Hs Inhibitor Inhibition >9.3 pIC50 - 1
⤷ pIC50 >9.3 (IC50 <5x10-10 M) [1]
LCK proto-oncogene, Src family tyrosine kinase Hs Inhibitor Inhibition >9.3 pIC50 - 1
⤷ pIC50 >9.3 (IC50 <5x10-10 M) [1]
SRC proto-oncogene, non-receptor tyrosine kinase Hs Inhibitor Inhibition >9.3 pIC50 - 1
⤷ pIC50 >9.3 (IC50 <5x10-10 M) [1]
YES proto-oncogene 1, Src family tyrosine kinase Hs Inhibitor Inhibition >9.3 pIC50 - 1
⤷ pIC50 >9.3 (IC50 <5x10-10 M) [1]
LYN proto-oncogene, Src family tyrosine kinase Hs Inhibitor Inhibition 9.1 pIC50 - 1
⤷ pIC50 9.1 (IC50 8x10-10 M) [1]
FYN proto-oncogene, Src family tyrosine kinase Hs Inhibitor Inhibition 8.7 pIC50 - 1
⤷ pIC50 8.7 (IC50 2.1x10-9 M) [1]
fyn related Src family tyrosine kinase Hs Inhibitor Inhibition 8.6 pIC50 - 1
⤷ pIC50 8.6 (IC50 2.8x10-9 M) [1]
HCK proto-oncogene, Src family tyrosine kinase Hs Inhibitor Inhibition 8.6 pIC50 - 1
⤷ pIC50 8.6 (IC50 2.8x10-9 M) [1]
BLK proto-oncogene, Src family tyrosine kinase Hs Inhibitor Inhibition 8.3 pIC50 - 1
⤷ pIC50 8.3 (IC50 5.4x10-9 M) [1]
ABL proto-oncogene 1, non-receptor tyrosine kinase Hs Inhibitor Inhibition 6.3 pIC50 - 1
⤷ pIC50 6.3 (IC50 4.79x10-7 M) [1]