clazakizumab   Click here for help

GtoPdb Ligand ID: 9195

Synonyms: ALD-518 | ALD518 | BMS-945429
Immunopharmacology Ligand
Compound class: Antibody
Comment: Clazakizumab is an investigational, aglycosylated, humanized (from a rabbit parental antibody) monoclonal antibody targeting interleukin-6, with anti-inflammatory potential [2].
Peptide sequence and structural information for this antibody are available from its IMGT/mAb-db record. BLAST peptide sequence analysis reveals identical matches with peptides claimed in patent US8062864 [3]. Results presented in the patent show that the preferred antibodies block interaction of IL-6 with the IL-6 receptor, but no precise binding affinity data is provided.
Selectivity at ligand targets
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
IL-6 Primary target of this compound Hs Antibody Binding >10.3 pKd - 3
⤷ pKd >10.3 (Kd <5x10-11 M) [3]