Compound class:
Synthetic organic
Comment: The discovery of the so-called STING agonist G10 by high throughput in vitro screening is reported in [1]. However, the authors could find no evidence of direct G10 binding to STING, despite experiments showing it being essential for the antiviral effects of the compound. The identity of the protein or factor engaged by G10 which stimulates the STING-dependent response is still being investigated.
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Bioactivity Comments |
G10 exhibits antiviral activity against new and old world alphavirus replication in vitro, being significantly more effective against the Chikungunya virus (IC50 ~8μM) [1]. Results show that STING is required for G10-mediated IRF3 activation, gene expression, and anti-Alphaviral activity. However, G10 is less potent than 2'3'-cGAMP, a canonical STING ligand. |