lutikizumab   Click here for help

GtoPdb Ligand ID: 9297

Synonyms: ABT-981 | E26.13-SS-X3 [6]
Immunopharmacology Ligand
Compound class: Antibody
Comment: Lutikizumab (ABT-981) is an investigational monoclonal antibody targeting IL-1α and IL-1β [6], designed using proprietary technology to create dual variable domain antibodies ('DVD-IgTM') [3]. DVD-Igs are single pharmaceutical agents capable of simultaneously targeting two mediators of disease. The unique feature of DVD-Igs is that each arm of the antibody contains two tandem variable domains, each capable of binding a different antigen (see Figure 2 in [6]).
Annotated peptide sequences for this antibody are available from its IMGT/mAb-DB record.
Selectivity at ligand targets
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
IL-1α Primary target of this compound Hs Antibody Binding 11.1 pKd - 6
⤷ pKd 11.1 (Kd 7.6x10-12 M) [6]
IL-1β Monkey Antibody Binding 10.8 pKd - 6
⤷ pKd 10.8 (Kd 1.53x10-11 M) [6]
IL-1β Primary target of this compound Hs Antibody Binding 10.7 pKd - 6
⤷ pKd 10.7 (Kd 2.1x10-11 M) [6]
IL-1α Monkey Antibody Binding 9.4 pKd - 6
⤷ pKd 9.4 (Kd 4.11x10-10 M) [6]
IL-1α Primary target of this compound Hs Antibody Binding 11.2 pEC50 - 6
⤷ pEC50 11.2 (EC50 6.4x10-12 M) [6]
IL-1β Primary target of this compound Hs Antibody Binding 11.1 pEC50 - 6
⤷ pEC50 11.1 (EC50 7.5x10-12 M) [6]