basimglurant

Ligand id: 9309

Name: basimglurant

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 1
Topological polar surface area 30.71
Molecular weight 325.08
XLogP 5.55
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
Basimglurant (RO4917523) is active in a number of experimental anxiety tests [1].
Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
mGlu5 receptor Hs Allosteric modulator Negative 7.4 pKi - 1
pKi 7.4 (Ki 3.6x10-8 M) [1]
Description: Reduction of antagonist MPEP binding to mGlu5 receptors in vitro