Synonyms: RDEA-3170 | RDEA3170
Compound class:
Synthetic organic
Comment: Verinurad (RDEA3170) is an investigational selective uric acid reabsorption inhibitor, functionally inhibiting the URAT1 (SLC22A12) transporter and being investigated for clinical efficacy in controlling uric acid levels in patients with gout. URAT1 is the renal transporter that regulates uric acid excretion from the body. Verinurad is structurally related to lesinurad (RDEA594), a URAT1 inhibitor already approved for treating hyperuricemia in gout.
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Bioactivity Comments |
A dissociation constant of 10nM for RDEA3170 vs. URAT1 is reported in a 2012 meeting abstract (see RDEA3170, a novel, high affinity URAT1 inhibitor binds to a central domain within URAT1). At this time there appears to be no peer reviewed confirmation of this data (Sept 2016). |
Selectivity at transporters | ||||||||||||||||||||||||||||||||||
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