BIX02189

Ligand id: 9380

Name: BIX02189

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 7
Topological polar surface area 64.68
Molecular weight 440.22
XLogP 5.57
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
BIX02189 also inhibits catalytic activity of ERK5 (mitogen-activated protein kinase 7; MAPK7), but does not inhibit closely related kinases MEK1, MEK2, ERK2, and JNK2. In a wider kinase screening panel BIX02189 inhibited RPS6KA6 (RSK4) by 94%, RPS6KA3 (RSK2) by 88%, p90RSK by 52%, LCK by 94%, KIT by 69%, JAK3 by 55%, FGFR1 by 76%, CSF1R (FMS) by 96% and ABL by 81%.
BIX02189 inhibits phosphorylation of ERK5 and activation of the downstream transcription factor target MEF2C (myocyte-specific enhancer factor 2C) [1].
Selectivity at human enzymes
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
mitogen-activated protein kinase kinase 5 Inhibitor Inhibition 8.8 pIC50 - 1
pIC50 8.8 (IC50 1.5x10-9 M) [1]
mitogen-activated protein kinase 7 Inhibitor Inhibition 7.2 pIC50 - 1
pIC50 7.2 (IC50 5.9x10-8 M) [1]
Selectivity at human catalytic receptors
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
transforming growth factor beta receptor 1 Inhibitor Inhibition 6.2 pIC50 - 1
pIC50 6.2 (IC50 5.8x10-7 M) [1]