BMS-536924

Ligand id: 9386

Name: BMS-536924

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 4
Rotatable bonds 5
Topological polar surface area 98.22
Molecular weight 479.17
XLogP 3.19
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
BMS-536924 inhibits other kinase enzymes in vitro- see Table 2 in [2].
Selectivity at enzymes
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
CYP3A4 Hs Inhibitor Inhibition 6.3 pIC50 - 2
pIC50 6.3 (IC50 5x10-7 M) [2]
Selectivity at catalytic receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
Insulin receptor Hs Inhibitor Inhibition 7.1 pIC50 - 2
pIC50 7.1 (IC50 7.3x10-8 M) [2]
Insulin-like growth factor I receptor Hs Inhibitor Inhibition 7.0 pIC50 - 2
pIC50 7.0 (IC50 1x10-7 M) [2]