AZD6738

Ligand id: 9390

Name: AZD6738

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 2
Rotatable bonds 4
Topological polar surface area 116.23
Molecular weight 412.17
XLogP 2.37
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
In cellular assays AZD6738 inhibits ATR kinase-dependent CHK1 phosphorylation with an IC50 of 74nM [1]. In kinase screens of related PI3K and protein PI3K-like kinases and a wider panel of biochemical kinase assays, AZD6738 inhibited PI3Kδ (IC50 6800nM), DYRK (IC50 10800nM) and PI3KC2G (20% inhibition at 1μM AZD6738).
Selectivity at human enzymes
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
ATR serine/threonine kinase Inhibitor Inhibition 9.0 pIC50 - 1
pIC50 9.0 (IC50 1x10-9 M) [1]
Description: Inhibition of isolated enzyme