ipragliflozin

Ligand id: 9394

Name: ipragliflozin

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 4
Rotatable bonds 4
Topological polar surface area 118.39
Molecular weight 404.11
XLogP 3.57
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at human transporters
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
Sodium/glucose cotransporter 2 Inhibitor Inhibition 8.1 pIC50 - 4
pIC50 8.1 (IC50 7.38x10-9 M) [4]
Description: Measuring inhibition of sodium-dependent [14C]AMG-uptake in CHO cells expressing hSGLT2.
Sodium/glucose cotransporter 1 Inhibitor Inhibition 5.7 pIC50 - 4
pIC50 5.7 (IC50 1.876x10-6 M) [4]
Description: Measuring inhibition of sodium-dependent [14C]AMG-uptake in CHO cells expressing hSGLT1.
Selectivity at mouse transporters
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
Sodium/glucose cotransporter 2 Inhibitor Inhibition 8.3 pIC50 - 4
pIC50 8.3 (IC50 5.64x10-9 M) [4]
Description: Measuring inhibition of sodium-dependent [14C]AMG-uptake in CHO cells expressing mSGLT2.
Sodium/glucose cotransporter 1 Inhibitor Inhibition 5.9 pIC50 - 4
pIC50 5.9 (IC50 1.38x10-6 M) [4]
Description: Measuring inhibition of sodium-dependent [14C]AMG-uptake in CHO cells expressing mSGLT1.
Selectivity at rat transporters
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
Sodium/glucose cotransporter 2 Inhibitor Inhibition 8.2 pIC50 - 4
pIC50 8.2 (IC50 6.37x10-9 M) [4]
Description: Measuring inhibition of sodium-dependent [14C]AMG-uptake in CHO cells expressing rSGLT2.
Sodium/glucose cotransporter 1 Inhibitor Inhibition 5.9 pIC50 - 4
pIC50 5.9 (IC50 1.166x10-6 M) [4]
Description: Measuring inhibition of sodium-dependent [14C]AMG-uptake in CHO cells expressing rSGLT1.