rotigotine

Ligand id: 941

Name: rotigotine

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 1
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 51.71
Molecular weight 315.17
XLogP 4.91
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at human GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
D2 receptor Agonist Agonist 10.2 pKi - 1
pKi 10.2 (Ki 6x10-11 M) [1]
D3 receptor Agonist Agonist 8.4 pKi - 1
pKi 8.4 (Ki 4x10-9 M) [1]
D4 receptor Agonist Agonist 7.3 pKi - 3
pKi 7.3 (Ki 5.5x10-8 M) [3]
D5 receptor Agonist Full agonist 6.0 pKi - 2
pKi 6.0 [2]
D1 receptor Agonist Full agonist 5.6 pKi - 2
pKi 5.6 [2]