rotigotine

Ligand id: 941

Name: rotigotine

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 1
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 51.71
Molecular weight 315.17
XLogP 4.91
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
D2 receptor Hs Agonist Agonist 10.2 pKi - 1
pKi 10.2 (Ki 6x10-11 M) [1]
D3 receptor Hs Agonist Agonist 8.4 pKi - 1
pKi 8.4 (Ki 4x10-9 M) [1]
D4 receptor Hs Agonist Agonist 7.3 pKi - 3
pKi 7.3 (Ki 5.5x10-8 M) [3]
D5 receptor Hs Agonist Full agonist 6.0 pKi - 2
pKi 6.0 [2]
D1 receptor Hs Agonist Full agonist 5.6 pKi - 2
pKi 5.6 [2]