BAY1161909

Ligand id: 9427

Name: BAY1161909

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 2
Rotatable bonds 9
Topological polar surface area 123.07
Molecular weight 559.17
XLogP 5.12
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
BAY1161909 works synergistically with the antimitotic cancer drug paclitaxel in vivo [1].
Selectivity at human enzymes
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
TTK protein kinase Inhibitor Inhibition >8.0 pIC50 - 1
pIC50 >8.0 (IC50 <1x10-8 M) [1]