compound 8ic [PMID: 19081254]

Ligand id: 9478

Name: compound 8ic [PMID: 19081254]

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 62.75
Molecular weight 467.33
XLogP 4.61
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
CCR4 antagonist activities of the synthesized compounds were determined by measuring the degree to which human CCL22-derived [35S]GTPγS was prevented from binding to the receptor.
Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
CCR4 Hs Antagonist Antagonist 7.7 pIC50 - 1
pIC50 7.7 (IC50 1.8x10-8 M) [1]