flupentixol

Ligand id: 948

Name: flupentixol

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View more information in the IUPHAR Pharmacology Education Project: flupentixol

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 52.01
Molecular weight 434.16
XLogP 4.91
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
D3 receptor Hs Antagonist Antagonist 9.0 pKi - 1
pKi 9.0 (Ki 1.1x10-9 M) [1]
D2 receptor Hs Antagonist Antagonist 8.8 pKi - 1
pKi 8.8 (Ki 1.5x10-9 M) [1]
D5 receptor Hs Antagonist Antagonist 8.1 pKi - 2
pKi 8.1 [2]
D1 receptor Hs Antagonist Antagonist 7.0 – 8.4 pKi - 2-3
pKi 7.0 – 8.4 [2-3]
Description: Note that this assay uses the cis form of the compound, whereas the approved drug is a racemic mixture of cis and trans molecules.