eCF309

Ligand id: 9571

Name: eCF309

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 9
Hydrogen bond donors 2
Rotatable bonds 7
Topological polar surface area 140.13
Molecular weight 383.17
XLogP 0.8
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
eCF309 is active in in vitro enzyme assays and acts as a potent cell cycle inhibitor in cell assays [1]. In a kinase screening panel 10 μM eCF309 inhibited mTOR by 99%. The only other wild type kinases inhibited by >60% were DNA-PK (90%), PI3Kγ (85%), and DDR1 (77%).
Selectivity at human enzymes
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
mechanistic target of rapamycin kinase Inhibitor Inhibition 8.1 pEC50 - 1
pEC50 8.1 (EC50 9x10-9 M) [1]
Description: In a cell viability assay.
mechanistic target of rapamycin kinase Inhibitor Inhibition 7.8 pIC50 - 1
pIC50 7.8 (IC50 1.5x10-8 M) [1]
Description: In a biochemical assys using recombinant wild type enzyme.
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Inhibitor Inhibition 6.0 pIC50 - 1
pIC50 6.0 (IC50 9.81x10-7 M) [1]
Description: In a biochemical assay.
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma Inhibitor Inhibition 5.9 pIC50 - 1
pIC50 5.9 (IC50 1.34x10-6 M) [1]
Description: In a biochemical assay.
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta Inhibitor Inhibition 5.7 pIC50 - 1
pIC50 5.7 (IC50 1.84x10-6 M) [1]
Description: In a biochemical assay.