risperidone

Ligand id: 96

Name: risperidone

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 0
Rotatable bonds 4
Topological polar surface area 49.58
Molecular weight 410.21
XLogP 4.01
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
5-HT7 receptor Rn Antagonist Inverse agonist 8.9 – 9.0 pKd - 6,13
pKd 8.9 – 9.0 [6,13]
5-HT2A receptor Hs Antagonist Inverse agonist 9.3 – 10.0 pKi - 5,7,14
pKi 9.3 – 10.0 [5,7,14]
D2 receptor Hs Antagonist Antagonist 9.4 pKi - 1
pKi 9.4 (Ki 4.4x10-10 M) [1]
5-HT2A receptor Rn Antagonist Antagonist 8.5 pKi - 2
pKi 8.5 [2]
5-HT7 receptor Hs Antagonist Inverse agonist 8.3 – 8.7 pKi - 12,16
pKi 8.3 – 8.7 [12,16]
α1A-adrenoceptor Hs Antagonist Antagonist 8.4 pKi - 17
pKi 8.4 [17]
α1B-adrenoceptor Hs Antagonist Antagonist 8.0 pKi - 17
pKi 8.0 [17]
5-HT1D receptor Hs Antagonist Antagonist 7.8 – 8.0 pKi - 9,14
pKi 7.8 – 8.0 [9,14]
H1 receptor Hs Antagonist Antagonist 7.6 – 7.8 pKi - 7,14
pKi 7.6 – 7.8 [7,14]
5-HT2C receptor Hs Antagonist Inverse agonist 7.5 – 7.6 pKi - 3,7
pKi 7.5 – 7.6 [3,7]
α1D-adrenoceptor Hs Antagonist Antagonist 7.4 pKi - 17
pKi 7.4 [17]
D3 receptor Hs Antagonist Antagonist 7.0 pKi - 10
pKi 7.0 [10]
5-HT1B receptor Hs Antagonist Antagonist 6.6 – 7.3 pKi - 8,14-15
pKi 6.6 – 7.3 [8,14-15]
5-HT1A receptor Hs Antagonist Antagonist 6.4 – 6.5 pKi - 11,14
pKi 6.4 – 6.5 [11,14]
5-HT1A receptor Rn Antagonist Antagonist 6.2 pKi - 6
pKi 6.2 [6]
5-HT6 receptor Rn Antagonist Inverse agonist 6.0 – 6.4 pKi - 6,13
pKi 6.0 – 6.4 [6,13]
5-ht1e receptor Hs Antagonist Antagonist 5.9 pKi - 14
pKi 5.9 [14]
5-HT1F receptor Hs Antagonist Antagonist 5.9 pKi - 14
pKi 5.9 [14]
5-HT6 receptor Hs Antagonist Antagonist 5.6 pKi - 4
pKi 5.6 [4]