betrixaban

Ligand id: 9602

Name: betrixaban

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 3
Rotatable bonds 9
Topological polar surface area 107.41
Molecular weight 451.14
XLogP 4.96
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
Betrixaban has limited hERG liability (Ki 1.8 μM) [1].
Selectivity at human enzymes
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
coagulation factor X Inhibitor Inhibition 9.9 pKi - 1
pKi 9.9 (Ki 1.17x10-10 M) [1]
Description: Inhibition of human factor Xa.