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Synonyms: Fibronum | L19TNF-alpha
Compound class:
Antibody
Comment: Onfekafusp alfa (Fibromun; L19-TNF) is a trimeric homodimer that forms from engineered peptides for the L19 antibody in scFv format fused to human TNF [1]. LIke bifikafusp alfa, Fibromun targets the TNF to the tumour microenvironment via L19 binding to the angiogenesis-associated isoform of fibronectin (specifically the extradomain B or EDB). Fibromun is being investigated as an immuno-oncology therapeutic. It is one of a growing number of so-called 'immunocytokines' entering clinical development.
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| Bioactivity Comments |
| The L19 scFv binds the ED-B domain of fibronectin with a dissociation constant of 0.054 nM [4]. |
