pateclizumab   Click here for help

GtoPdb Ligand ID: 9854

Synonyms: MLTA3698A | PRO283698 | RG7416
Immunopharmacology Ligand
Compound class: Antibody
Comment: Pateclizumab is a humanized anti-lymphotoxin alpha (LTA) monoclonal antibody that is being investigated for anti-inflammatory potential. Peptide sequences for the heavy and light chains of pateclizumab are 100% matches to sequences 106 and 107 that are claimed in Genentech's patent US7923011B2 [1]. Sequences 106 and 107 identify pateclizumab as antibody 2C8.vX as defined in the patent.
Bioactivity Comments
Safety, pharmacokinetics, and biologic activity of pateclizumab are reported in Emu et al. (2012) [2].
Selectivity at ligand targets
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
lymphotoxin-α Primary target of this compound Hs Antibody Binding 10.3 pEC50 - 1
⤷ pEC50 10.3 (EC50 5x10-11 M) [1]
Description: Binding to the LTα trimer LTα3