Synonyms: BMS 509744 | BMS509744 | compound 3 [PMID:16682193]
Compound class:
Synthetic organic
Comment: BMS-509744 is an inhibitor of the Tec family tyrosine kinase, interleukin-2-inducible T cell kinase (ITK) [1]. ITK inhibitors are being investigated for potential immunosuppressive and/or anti-inflammatory activities.
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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Bioactivity Comments |
BMS-509744 inhibits IL-2 secretion by Kurkat cells with an IC50 of 250nM, inhibits IL-2 production in mice in vivo, and reduces lung inflammation in a mouse model of ovalbumin induced allergy/asthma [1]. |
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