thioridazine

Ligand id: 100

Name: thioridazine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 4
Topological polar surface area 57.08
Molecular weight 370.15
XLogP 5.63
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used in the treatment of psychosis and schizophrenia. Due to the risk of elongation of the QTc interval, this drug should only be used in patients who have failed to respond to other antipsychotic medications. Due to its cardiotoxicity the drug has been withdrawn from sale in several countries. Thioridazine also has antiemetic activity.
Mechanism Of Action and Pharmacodynamic Effects
Antagonist at dopaminergic receptors and α-adrenoceptors in the brain. Drug action inhibits the release of hypothalamic and hypophyseal hormones.
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