suramin

Ligand id: 1728

Name: suramin

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 29
Hydrogen bond donors 12
Rotatable bonds 22
Topological polar surface area 534.03
Molecular weight 1296.05
XLogP 1.05
No. Lipinski's rules broken 3

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used in the treatment of human sleeping sickness, onchocerciasis and other parasite-caused diseases. There is no information regarding approval for clinical use of this drug on the US FDA or European Medicines Agency websites. Individual national approval agencies may have granted marketing authorisation.
Mechanism Of Action and Pharmacodynamic Effects
The exact mechanism of action of suramin is unknown, but likely involves antipurinergic activity via antagonism of P2 purinoceptors.