thiothixene

Ligand id: 212

Name: thiothixene

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 0
Rotatable bonds 5
Topological polar surface area 77.54
Molecular weight 443.17
XLogP 3.22
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Antipsychotic used in the management of schizophrenia.
Mechanism Of Action and Pharmacodynamic Effects
Antagonist at a range of postsynaptic receptors, namely dopaminergic, serotonergic, histaminergic, and alpha-1 and -2 adrenergic, and muscarinic receptors. For an overview of the physiological effects resulting from the antagonism of these receptors by thiothixine, please see the entry on DrugBank linked to from this ligand page.
External links