progesterone

Ligand id: 2377

Name: progesterone

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 1
Topological polar surface area 34.14
Molecular weight 314.22
XLogP 4.83
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used in help treat infertilty in women with progesterone deficiency, and in the treatment of secondary amenorrhea. Also used in the reduction of endometrial hyperplasia incidence and risk of endometrial carcinoma in postmenopausal women receiving estrogen replacement therapy, and the treatment of abnormal uterine bleeding due to hormonal imbalance.
Mechanism Of Action and Pharmacodynamic Effects
Agonist of progesterone and estrogen receptors. When bound to the progesterone receptor in the female reproductive tract, mammary gland, hypothalamus and pituitary, progesterone slows the release of GnRH and reduce the release of LH. Additionally, the action of progesterone on the endometrium is to promote secretion rather than proliferation of the endometrial wall.
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