diclofenac

Ligand id: 2714

Name: diclofenac

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 4
Topological polar surface area 49.33
Molecular weight 295.02
XLogP 4.12
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Diclofenac is used to treat pain or inflammation caused by osteoarthritis and rheumatoid arthritis, but is also used to treat other conditions which benefit from the analgesic and antipyretic properties of NSAIDs.
Mechanism Of Action and Pharmacodynamic Effects
In addition to inhibiting prostaglandin synthesis (via inhibition of COX-1 and COX-2; prostaglandins normally sensitize nociceptors), diclofenac appears to inhibit leukocyte migration at inflammarory sites.