phenobarbital

Ligand id: 2804

Name: phenobarbital

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 2
Topological polar surface area 75.27
Molecular weight 232.08
XLogP 2.77
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used in the treatment of all types of seizure with the exception of absence seizures.
Mechanism Of Action and Pharmacodynamic Effects
Increases synaptic inhibition by action of GABAA receptors. This has the effect of elevating seizure threshold and reduces the spread of seizure activity from a seizure focus.
Due to the complex and varied nature of the precise subunit composition of GABAA receptors, and a paucity of affinity data with definitive molecular details, we have not tagged a primary target for this drug.
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