bicalutamide

Ligand id: 2863

Name: bicalutamide

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 7
Topological polar surface area 115.64
Molecular weight 430.06
XLogP 3.31
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used along with luteinizing hormone-releasing hormone analogs to treat metastatic prostate cancer.
Mechanism Of Action and Pharmacodynamic Effects
Bicalutamide acts by antagonising the proliferative actions of the adrenal and testicular androgens on normal and malignant prostatic tissue. Since most prostate cancers are androgen-dependent they are sensitive to this type of 'chemical castration'.
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