celecoxib

Ligand id: 2892

Name: celecoxib

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 4
Topological polar surface area 86.36
Molecular weight 381.08
XLogP 5.42
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Celecoxib is used to treat osteoarthritis, rheumatoid arthritis, acute pain, painful menstruation and menstrual symptoms. It is also used to reduce the number of colon and rectum polyps in patients with familial adenomatous polyposis.
Mechanism Of Action and Pharmacodynamic Effects
Celecoxib is a selective noncompetitive inhibitor of cyclooxygenase-2 (COX-2) and does not inhibit COX-1. Inhibition of COX-2 reduces synthesis of prostaglandin precursors from arachadonic acid.