fluvastatin

Ligand id: 2951

Name: fluvastatin

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 3
Rotatable bonds 8
Topological polar surface area 82.69
Molecular weight 411.18
XLogP 4.96
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Fluvastatin is used to treat hypercholesterolaemia and to reduce the risk of developing cardiovascular disease.
Mechanism Of Action and Pharmacodynamic Effects
Statins lower plasma cholesterol levels by inhibiting HMG-CoA reductase, the enzyme responsible for the rate limiting step of conversion of HMG-CoA to mevalonic acid in hepatic cholesterol biosynthesis.