cabergoline

Ligand id: 37

Name: cabergoline

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 11
Topological polar surface area 67.92
Molecular weight 451.29
XLogP 3.04
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Cabergoline is used to treat hyperprolactinemic disorders and to manage symptoms of Parkinson's disease.
Mechanism Of Action and Pharmacodynamic Effects
Cabergoline stimulation of dopamine D2 receptors in the nigrostriatal pathway leads to improvements in coordinated muscle activity in those with movement disorders. In lactotrophs, stimulation of dopamine D2 receptors causes inhibition of adenylyl cyclase and results in decreased prolaction secretion.
External links