carbenoxolone

Ligand id: 4151

Name: carbenoxolone

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 6
Topological polar surface area 117.97
Molecular weight 570.36
XLogP 6.86
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Carbenoxolone is not approved by the US FDA or EMA. Its use is authorised by other national approval agencies, where it is used for the treatment of peptic, esophageal and oral ulceration and inflammation.
Mechanism Of Action and Pharmacodynamic Effects
Carbenoxolone inhibits 11β-hydroxysteroid dehydrogenase type 1, and through this mechanism increases levels of the active glucocorticoid, cortisol. Cortisol-induced activation of the glucocorticoid receptor produces an antiinflammatory response.