flurbiprofen

Ligand id: 4194

Name: flurbiprofen

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 3
Topological polar surface area 37.3
Molecular weight 244.09
XLogP 5.51
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Flurbiprofen is approved to treat the pain and inflammation associated with rheumatic diseases and other musculoskeletal disorders, as well as dysmenorrhoea, migraine and as postoperative analgesia.
Mechanism Of Action and Pharmacodynamic Effects
Flurbiprofen reversibly inhibits cyclooxygenase (COX) enzymes 1 and 2, causing a reduction in synthesis of pro-inflammatory prostaglandins.