triamterene

Ligand id: 4329

Name: triamterene

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 3
Rotatable bonds 1
Topological polar surface area 129.62
Molecular weight 253.11
XLogP 1.37
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Anti-diuretic used in the treatment of edema associated with congestive heart failure, hepatic cirrhosis, and nephrotic syndrome, and also in the treatment of other forms of edema including idiopathic and steroid-induced.
Mechanism Of Action and Pharmacodynamic Effects
Inhibits epithelial sodium channels (ENaCs) on principal cells in the late distal convoluted tubule and collecting tubule, inhibiting sodium reabsorption and increasing water loss. This action promotes potassium excretion through apical potassium channels, thereby inhibiting potassium excretion.
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