digoxin

Ligand id: 4726

Name: digoxin

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 14
Hydrogen bond donors 6
Rotatable bonds 7
Topological polar surface area 203.06
Molecular weight 780.43
XLogP 2.17
No. Lipinski's rules broken 2

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Digoxin is used to treat congestive heart failure and atrial fibrillation
Mechanism Of Action and Pharmacodynamic Effects
Digoxin inhibits the Na-K-ATPase membrane pump, resulting in an increase in intracellular sodium and calcium concentrations, which appears to promote activation of the contractile proteins actin and myosin.