sildenafil

Ligand id: 4743

Name: sildenafil

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 9
Hydrogen bond donors 2
Rotatable bonds 7
Topological polar surface area 117.18
Molecular weight 475.21
XLogP 1.18
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used in the treatment of erectile dysfunction (ED) and pulmonary arterial hypertension (PAH, under brand name Revatio®).
Mechanism Of Action and Pharmacodynamic Effects
Sildenafil is a selective phosphodiesterase type 5 (PDE5) inhibitor. Such inhibitors block the degradative action of PDE5 on cGMP in the smooth muscle cells lining the blood vessels supplying the corpus cavernosum of the penis. This action dilates these blood vessels allowing blood ingress and leads to functional erection.
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