tamsulosin

Ligand id: 488

Name: tamsulosin

IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: tamsulosin

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 11
Topological polar surface area 108.26
Molecular weight 408.17
XLogP 2.68
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used in the symptomatic relief of benign prostatic hyperplasia.
A 2015 report indicates that tamsulosin increases expulsion of larger (>10mm) kidney stones [4] in a double-blind, placebo-controlled, randomized, multicenter clinical trial. This result suggests that terazosin and doxazosin, which belong to the same drug class, may provide the same effect.
Mechanism Of Action and Pharmacodynamic Effects
Selective antagonist for α1A- and α1D-adrenoceptors in the prostate, prostatic capsule, prostatic uretha and bladder neck causing relaxation of smooth muscles and therefore decreasing urinary outflow resistance in men.
External links