captopril

Ligand id: 5158

Name: captopril

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 4
Topological polar surface area 96.41
Molecular weight 217.08
XLogP 0.64
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Like other ACE inhibitors captopril is used to treat hypertension.
Mechanism Of Action and Pharmacodynamic Effects
Captopril competes with angiotensisn I for binding to ACE thereby inhibiting its enzymatic conversion to angiotensin II. Reduced levels of angiotensin II leads to reduced blood pressure.