clonidine

Ligand id: 516

Name: clonidine

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 2
Topological polar surface area 36.42
Molecular weight 229.02
XLogP 2.4
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Clonidine is a an imidazoline-derivative hypotensive agent with a variety of clinical uses including as an epidural infusion, for the prophylaxis of vascular migraine headaches, treatment of severe dysmenorrhea and management of severe cancer pain. In the US this drug is used to manage ADHD in children above 6 years of age.
Mechanism Of Action and Pharmacodynamic Effects
Clonidine has similar agonist affinity for all three α2-adrenergic receptors (α2-ARs). The drug is able to cross the blood-brain barrier where it acts on presynaptic α2A- and α2C-ARs to inhibit the release of noradrenaline from sympathetic nerves. This decreases sympathetic tone and results in decreased blood pressure and heart rate. Sedation and analgesia are mediated by centrally located α2A-ARs.