propofol

Ligand id: 5464

Name: propofol

IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: propofol

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 0
Hydrogen bond donors 1
Rotatable bonds 2
Topological polar surface area 20.23
Molecular weight 178.14
XLogP 4.42
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used in the induction and maintenance of anaesthesia and the management of refractory status epilepticus.
Mechanism Of Action and Pharmacodynamic Effects
The inhibitory function of GABA through GABAA channels is enhanced by propofol. Propofol binding sites have been identified on recombinantly expressed human GABAA channels [3].
External links