eprosartan

Ligand id: 588

Name: eprosartan

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 10
Topological polar surface area 120.66
Molecular weight 424.15
XLogP 5.51
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used in the treatment of hypertension, alone or in combinatiin with other agents.
Mechanism Of Action and Pharmacodynamic Effects
Eprosartan acts on the renin-angiotensin system to decrease total peripheral resistance; eprosartan causes vascular dilation by preventing binding of endogenous angiotensin II to AT1 receptors in vascular smooth muscle cells and additionally inhibits sympathetic norepinephrine production, which reduces blood pressure further.