lifibrol   Click here for help

GtoPdb Ligand ID: 5885

Synonyms: K 12148 | K12.148 | U-83860
Compound class: Synthetic organic
Comment: Lifibrol is a model compound being investigated in the development of novel pharmacotherapies for dyslipidaemia [1]. The compoound appears to be a cholesterol synthesis inhibitor.
The INN document for lifibrol specifies that it is a racemic mixture of two enatiomers. We do not specify stereochemistry in our structure therefore this entry represents the mixture.
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 8
Topological polar surface area 66.76
Molecular weight 342.18
XLogP 4.92
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES OC(COc1ccc(cc1)C(=O)O)CCc1ccc(cc1)C(C)(C)C
Isomeric SMILES OC(COc1ccc(cc1)C(=O)O)CCc1ccc(cc1)C(C)(C)C
InChI InChI=1S/C21H26O4/c1-21(2,3)17-9-4-15(5-10-17)6-11-18(22)14-25-19-12-7-16(8-13-19)20(23)24/h4-5,7-10,12-13,18,22H,6,11,14H2,1-3H3,(H,23,24)
InChI Key LNXBEIZREVRNTF-UHFFFAOYSA-N
No information available.
Summary of Clinical Use Click here for help
A Phase 3 clinical trial comparing the mechanisms of action of lifibrol and pravastatin has been completed (see NCT01057654).
Mechanism Of Action and Pharmacodynamic Effects Click here for help
The mechanism of action of this compound is different from the one of statins but remains unknown. Findings from early clinical testing suggets that it may enhance sterol excretion and/or reduce cholesterol absorption, in addition to inducing 7α-hydroxylase actibity [2].