Synonyms: AG-F-89549 | EVP4593
Compound class:
Synthetic organic
Comment: This compound potently inhibits nuclear factor-κB (NFκB) activation and LPS-induced TNFα production [7]. Its discovery is reported in [7] where it is compound 11q.
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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No information available. |
Mechanism Of Action and Pharmacodynamic Effects |
NFκB is a transcription factor central to the regulation of proinflammatory cytokine transcription. NFκB enhances the production of cytokines such as TNFα, IL-1β, IL-6, and IL-8, which are involved in the development of acute inflammatory responses associated with autoimmune diseases and allergies [2-4,6,8]. NFκB is a target for the development of therapeutic inhibitors. |