cholic acid

Ligand id: 609

Name: cholic acid

Abbreviated name: CA

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 4
Rotatable bonds 4
Topological polar surface area 97.99
Molecular weight 408.29
XLogP 4.09
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
The FDA approved cholic acid (Cholbam) in capsule form for the treatment of rare bile acid synthesis disorders in pediatric and adult patients. These disorders include those arising from defects in a single enzyme, and peroxisomal disorders including Zellweger spectrum disorders.
Mechanism Of Action and Pharmacodynamic Effects
In patients with defects in cholic acid synthesis due to functional enzyme deficiency, supplementation with cholic acid can help ensure correct levels of bile flow and aid absorption of fats and fat-soluable vitamins.