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Ligand id: 6316
View more information in the IUPHAR Pharmacology Education Project: saxagliptin
Molecular properties generated using the CDK
|No information available.|
|Summary of Clinical Use|
|Used in the treatment of type 2 diabetes.
Kombiglyze XR®, is an extended release, fixed-dose formulation containing saxagliptin and the antidiabetic drug metformin HCl, used to provide more stable glucose levels in patients with type 2 diabetes.
|Mechanism Of Action and Pharmacodynamic Effects|
|Saxagliptan is an inhibitor of dipeptidyl peptidase-4. The inhibition of this enzyme increases levels of glucagon like peptide 1 which inhibits glucagon production from pancreatic alpha cells and increases production of insulin from pancreatic beta cells.|
For extended ADME data see the following:
Electronic Medicines Compendium (eMC)
European Medicines Agency (EMA)