saxagliptin

Ligand id: 6316

Name: saxagliptin

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 3
Topological polar surface area 90.35
Molecular weight 315.19
XLogP 0.73
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used in the treatment of type 2 diabetes.
Kombiglyze XR®, is an extended release, fixed-dose formulation containing saxagliptin and the antidiabetic drug metformin HCl, used to provide more stable glucose levels in patients with type 2 diabetes.
Mechanism Of Action and Pharmacodynamic Effects
Saxagliptan is an inhibitor of dipeptidyl peptidase-4. The inhibition of this enzyme increases levels of glucagon like peptide 1 which inhibits glucagon production from pancreatic alpha cells and increases production of insulin from pancreatic beta cells.
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