trandolaprilat

Ligand id: 6455

Name: trandolaprilat

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 3
Rotatable bonds 9
Topological polar surface area 106.94
Molecular weight 402.22
XLogP 4.74
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Metabolic product of the prodrug trandolapril, an ACE inhibitor for mild to moderate hypertension, improved survival following myocardial infarction, congestive heart failure, and to slow renal disease.
Mechanism Of Action and Pharmacodynamic Effects
Inhibits the conversion of angiotensin I to angiotensin II, which in turn decreases blood pressure. Also causes an increase in plasma renin activity.