cilazaprilat

Ligand id: 6461

Name: cilazaprilat

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 3
Rotatable bonds 7
Topological polar surface area 110.18
Molecular weight 389.2
XLogP 3.44
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
ACE inhibitor used for the treatment of hypertension and congestive heart failure
Mechanism Of Action and Pharmacodynamic Effects
Cilazaprilat competes with angiotensisn I for binding to ACE thereby inhibiting its enzymatic conversion to angiotensin II. Reduced levels of angiotensin II leads to reduced blood pressure. However, we have been unable to find molecular data for this drug at the human target, to substantiate its MMOA.